LITTLE KNOWN FACTS ABOUT TRAMADOL (RETARD).

Opioid action is due to both of those lower affinity binding with the dad or mum compound and better affinity binding of your O-demethylated metabolite M1 to μ-opioid receptors. In animal styles, M1 is as much as six instances much more strong than tramadol in developing analgesia and 200 moments far more strong in μ-opioid binding.The website is